Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor

The trophic effect of ciliary neurotrophic factor on injured masseter muscle in rat

Objective(s): Occlusal trauma is one of the most common forms of oral biting dysfunction. Long-term occlusal trauma could weaken the stomatognathic system; especially damage one’s masticatory muscle. Through using the rat model, this study investigated the trophic effect of ciliary neurotrophic factor (CNTF) on injured masseter muscle. Materials and Methods: Male Wistar rats (n=36) were random...

Cloning, Mapping, and Retinal Expression of the Canine Ciliary Neurotrophic Factor Receptor α (CNTFRα)

METHODS. The complete coding sequence of the canine CNTFR cDNA was cloned, and radiation hybrid (RH) mapping was used to determine the chromosomal localization of the gene. CNTFR mRNA expression in retina and other tissues was examined by reverse transcription–polymerase chain reaction. The cellular distribution of CNTFR in the canine retina was studied by in situ hybridization and immunocytoch...

Ciliary neurotrophic factor: pharmacokinetics and acute-phase response in rat.

Ciliary neurotrophic factor (CNTF) supports the survival of motoneurons in vitro and in vivo. Recombinant CNTF is an investigational drug for the treatment of amyotrophic lateral sclerosis. We determined the pharmacokinetics of radioiodinated CNTF after intravenous injection into rats. CNTF shows a biphasic clearance with an initial plasma half-life of 2.9 minutes and is removed from the circul...

Cellular and Molecular Studies of Ciliary Neurotrophic Factor Receptor Alpha Expression and Ciliary Neurotrophic Factor Mediated Neuroprotection in the Canine Retina

the trophic effect of ciliary neurotrophic factor on injured masseter muscle in rat

objective(s): occlusal trauma is one of the most common forms of oral biting dysfunction. long-term occlusal trauma could weaken the stomatognathic system; especially damage one’s masticatory muscle. through using the rat model, this study investigated the trophic effect of ciliary neurotrophic factor (cntf) on injured masseter muscle. materials and methods: male wistar rats (n=36) were randoml...